Examining the antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants

Antiviral effect of tenofovir - antivirotic developed by prof. A. Holý - onto model plant DNA virus Cauliflower mosaic virus was evaluated. Six to nine weeks after tenofovir treatment of infected Brassica pekinensis, virus was not detectable by any routine molecular methods used. Detailled study showed, that tenofovir in plants is acting like nucleotide - basic DNA element. Therefore, the principle of its effect on plant DNA viruses is apparently similar as in the case of animal viruses: tenofovir blocks reproduction of virus by incorporating itself into virus DNA when replicating.

• Špak Josef, Votruba I., Pavingerová Daniela, Holý A., Špaková Vlastimila, Petrzik Karel:Antiviral activity of tenofovir against Cauliflower mosaic virus and its metabolism in Brassica pekinensis plants. Antiviral Research 92: 378-381, 2011 [IF = 4.301].-> Abstract / Full-text online