HR Excellence in Science
Total found: 59 records
Lukeš J., Speijer D., Panicucci Zíková A., Alfonzo J., Hashimi H., Field M. (2023) Trypanosomes as a magnifying glass for cell and molecular biology Trends in Parasitology 39: 902–912.
DOI: 10.1016/j.pt.2023.08.004

Documents to download:
Lukes_2023_TrendsParasitol (pdf)
Taleva G., Husová M., Panicucci B., Hierro-Yap C., Pineda E., Biran M., Moos M., Butter F., Šimek P., Bringaud F., Panicucci Zíková A. (2023) Mitochondrion of the Trypanosoma brucei long slender bloodstream form is capable of ATP production by substrate-level phosphorylation PLoS pathogens 19: e1011699.
DOI: 10.1371/journal.ppat.1011699
Valach M., Benz C., Aguilar L.C., Gahura O., Faktorová D., Zíková A., Oeffinger M., Burger G., Gray M., Lukeš J. (2023) Miniature RNAs are embedded in an exceptionally protein-rich mitoribosome via an elaborate assembly pathway Nucleic Acids Research 51: 6443–6460.
DOI: 10.1093/nar/gkad422

Documents to download:
Valach_2023_NucAcidRes (pdf)
Wong J., Panicucci Zíková A., Gahura O. (2023) The ancestral shape of the access proton path of mitochondrial ATP synthases revealed by a split subunit-a Molecular Biology and Evolution 40: msad146.
DOI: 10.1093/molbev/msad146
Gahura O., Chauhan P., Panicucci Zíková A. (2022) Mechanisms and players of mitoribosomal biogenesis revealed in trypanosomatids Trends in Parasitology 38: 1053-1067.
DOI: 10.1016/j.pt.2022.08.010
Gahura O., Mühleip A., Hierro-Yap C., Panicucci B., Jain M., Hollaus D., Slapničková M., Panicucci Zíková A., Amunts A. (2022) An ancestral interaction module promotes oligomerization in divergent mitochondrial ATP synthases Nature Communications 13: 5989.
DOI: 10.1038/s41467-022-33588-z
Klejch T., Keough D., King G., Doleželová E., Česnek M., Buděšínský M., Panicucci Zíková A., Janeba Z., Guddat L., Hocková D. (2022) Stereo-defined acyclic nucleoside phosphonates are selective and potent inhibitors of parasite 6-oxopurine phosphoribosyltransferases Journal of Medicinal Chemistry 65: 4030–4057.
DOI: 10.1021/acs.jmedchem.1c01881
Lemke C., Jílková A., Ferber D., Braune A., On A., Johe P., Panicucci Zíková A., Schirmeister T., Mareš M., Horn M., Gütschow M. (2022) Two Tags in One Probe: Combining Fluorescence- and Biotin-based Detection of the Trypanosomal Cysteine Protease Rhodesain Chemistry-A European Journal 28: e202201636.
DOI: 10.1002/chem.202201636
Panicucci Zíková A. (2022) Mitochondrial adaptations throughout the Trypanosoma brucei life cycle Journal of Eukaryotic Microbiology 69: e12911.
DOI: 10.1111/jeu.12911
Štěpánek O., Čmoková A., Procházková E. , Grobárová V., Černý J., Slapničková M., Panicucci Zíková A., Kolařík M., Baszczyňski O. (2022) Piperazine-Modified Ketoconazole Derivatives Show Increased Activity against Fungal and Trypanosomatid Pathogens ChemMedChem 17: e202200385.
DOI: 10.1002/cmdc.202200385
Vaňková K., Doleželová E., Tloušťová E., Hocková D., Panicucci Zíková A., Janeba Z. (2022) Synthesis and anti-trypanosomal evaluation of novel N-branched acyclic nucleoside phosphonates bearing 7-aryl-7-deazapurine nucleobase European Journal of Medicinal Chemistry 239: 114559.
DOI: 10.1016/j.ejmech.2022.114559
Cadena L., Gahura O., Panicucci B., Panicucci Zíková A., Hashimi H. (2021) Mitochondrial Contact Site and Cristae Organization System and F1FO-ATP Synthase Crosstalk Is a Fundamental Property of Mitochondrial Cristae mSphere 16: e0032721.
DOI: 10.1128/mSphere.00327-21

Documents to download:
Cadena_2021_mSphere (pdf)
Doleželová E., Klejch T., Špaček P., Slapničková M., Guddat L., Hocková D., Zíková A. (2021) Acyclic nucleoside phosphonates with adenine nucleobase inhibit Trypanosoma brucei adenine phosphoribosyltransferase in vitro Scientific Reports 11: 13317.
DOI: 10.1038/s41598-021-91747-6
Gahura O., Hierro-Yap C., Zíková A. (2021) Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthase Parasitology 148: 1151–1160.
DOI: 10.1017/S0031182021000202
Hierro-Yap C., Šubrtová , Gahura O., Panicucci B., Dewar C., Chinopoulos C., Schnaufer A., Zíková A. (2021) Bioenergetic consequences of FoF1-ATP synthase/ATPase deficiency in two life cycle stages of Trypanosoma brucei Journal of Biological Chemistry 296: 100357.
DOI: 10.1016/j.jbc.2021.100357
Kalčic F., Frydrych J., Doleželová E., Slapničková M., Pachl P., Slavětínská L.P., Hocková D., Zíková A., Janeba Z. (2021) C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase European Journal of Medicinal Chemistry 225: 113798.
DOI: 10.1016/j.ejmech.2021.113798
Nguyen V.H., Tichý M., Rožánková S., Pohl R., Doleželová E., Tloušťová E., Slapničková M., Zíková A., Hocek M. (2021) Synthesis and anti-trypanosomal activity of 3'-fluororibonucleosides derived from 7-deazapurine nucleosides Bioorganic & Medicinal Chemistry Letters 40: 127957.
DOI: 10.1016/j.bmcl.2021.127957
Perlíková P., Krajczyk A., Doleželová E., Slapničková M., Milisavljevic N., Slavětínská L.P., Tloušt'ová E., Gurská S., Džubák P., Hajdúch M., Panicucci Zíková A., Hocek M. (2021) Synthesis and Antitrypanosomal Activity of 6-Substituted 7-Methyl-7-deazapurine Nucleosides ACS Infectious Diseases 7: 917–926.
DOI: 10.1021/acsinfecdis.1c00062
Serricchio M., Hierro-Yap C., Schädeli D., Hamidane H.B., Hemphill A., Graumann J., Panicucci Zíková A., Bütikofer P. (2021) Depletion of cardiolipin induces major changes in energy metabolism in Trypanosoma brucei bloodstream forms Faseb Journal 35: e21176.
DOI: 10.1096/fj.202001579RR
Tobiasson V., Gahura O., Aibara S., Baradaran R., Panicucci Zíková A., Amunts A. (2021) Interconnected assembly factors regulate the biogenesis of mitoribosomal large subunit Embo Journal e106292.
DOI: 10.1101/2020.06.28.176446

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