HR Excellence in Science

RNDr. Luděk Eyer, Ph.D.

Position Research Scientist - Laboratory of Arbovirology
Disease Vectors and Pathogens
Institute of Parasitology

Contact details +420 533331911
eyer@vri.cz
316

Total found: 39 records
Holoubek J., Salát J., Kotouček J., Kastl T., Vancová M., Huvarová I., Bednář P., Bednářová K., Růžek D., Renčiuk D., Eyer L. (2024) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research 221: 105767.
DOI: 10.1016/j.antiviral.2023.105767
Vojnikova M., Sukupová M., Štefánik M., Straková P., Haviernik J., Kapolkova K., Gruberova E., Raskova K., Michalkova H., Švec P., Kudlickova M.P., Huvarová I., Růžek D., Salát J., Pekarik V., Eyer L., Heger Z. (2024) Nanoformulation of the Broad-Spectrum Hydrophobic Antiviral Vacuolar ATPase Inhibitor Diphyllin in Human Recombinant H-ferritin International Journal of Nanomedicine 19: 3907–3917.
DOI: 10.2147/IJN.S452119
Eyer L., Seley-Radtke K., Růžek D. (2023) New directions in the experimental therapy of tick-borne encephalitis Antiviral Research 210: 105504.
DOI: 10.1016/j.antiviral.2022.105504
Holoubek J., Salát J., Kotouček J., Kastl T., Vancová M., Huvarová I., Bednář P., Bednářová K., Růžek D., Renčiuk D., Eyer L. (2023) Antiviral activity of porphyrins and porphyrin-like compounds against tick-borne encephalitis virus: blockage of the viral entry/fusion machinery by photosensitization-mediated destruction of the viral envelope Antiviral Research 221: 105767.
DOI: 10.1016/j.antiviral.2023.105767
Kobayashi S., Fukuda Y., Yoshii K., Thammahakin P., Maezono K., Eyer L., Růžek D., Kariwa H. (2023) Development of recombinant West Nile virus expressing mCherry reporter protein Journal of Virological Methods 37: 114744.
DOI: 10.1016/j.jviromet.2023.114744
Mariewskaya K.A., Gvozdev D.A., Chistov A.A., Straková P., Huvarová I., Svoboda P., Kotouček J., Ivanov N.M., Krasilnikov M.S., Zhitlov M.Y., Pak A.M., Mikhnovets I.E., Nikitin T.D., Korshun V.A., Alferova V.A., Mašek J., Růžek D., Eyer L., Ustinov A.V. (2023) Membrane-targeting perylenylethynylphenols inactivate medically important coronaviruses via the singlet oxygen photogeneration mechanism Molecules 28: 6278.
DOI: 10.3390/molecules28176278
Mikhnovets I.E., Holoubek J., Panina I.S., Kotouček J., Gvozdev D.A., Chumakov D.A., Krasilnikov M.S., Zhitlov M.Y., Gulyak E.L., Chistov A.A., Nikitin T.D., Korshun V.A., Efremov R.G., Alferova V.A., Růžek D., Eyer L., Ustinov A.V. (2023) Alkyl derivatives of perylene photosensitizing antivirals: towards understanding the influence of lipophilicity International Journal of Molecular Sciences 24: 16483.
DOI: 10.3390/ijms242216483
Penjarla S., Reddy P.Y., Penta S., Sanghvi Y., Eyer L., Štefánik M., Krátká Z., Růžek D., Banerjee S. (2023) Synthesis and antiviral activity of 2′-modified L-nucleoside analogues ChemistrySelect 8: e202303585.
DOI: 10.1002/slct.202303585
Penjarla S., Reddy P.Y., Penta S., Sanghvi Y.S., Eyer L., Štefánik M., Růžek D., Banerjee S. (2023) Efficient synthesis of novel 2-deoxy-C-nucleosides containing oxa and thiadiazole derivatives and their biological activity Journal of Molecular Structure 1292: 136099.
DOI: 10.1016/j.molstruc.2023.136099
Straková P., Bednar P., Kotouček J., Holoubek J., Fořtová A., Svoboda P., Štefánik M., Huvarová I., Simeckova P., Korshun V.A., Růžek D., Eyer L. (2023) Antiviral activity of singlet oxygen-photogenerating perylene compounds against SARS-CoV-2: Interaction with the viral envelope and photodynamic virion inactivation Virus Research 334: 199158.
DOI: 10.1016/j.virusres.2023.199158
Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B., Eyer L., Hönig V., Palus M., Růžek D., Vyhlídalová T., Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine 76: 103818.
DOI: 10.1016/j.ebiom.2022.103818
Štefánik M., Bhosale D., Straková P., Haviernik J., Fojtikova M., Dufkova L., Huvarová I., Salát J., Růžek D., Miller A., Eyer L. (2022) Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses Viruses-Basel 14: 354.
DOI: 10.3390/v14020354
Thames J.E., Eyer L., Seley-Radtke K. (2022) Small molecule-based inhibitors for treatment of tick-borne encephalitis virus infection: Nucleoside analogs and nonnucleoside antivirals, Chapter II. In: D.I. Osolodkin (Ed.), Annual Reports in Medicinal Chemistry, Medicinal Chemistry of Tick-Borne Encephalitis. 256: 58: 55-92.
DOI: 10.1016/bs.armc.2022.08.003
Dejmek M., Konkolová E., Eyer L., Straková P., Svoboda P., Šála M., Krejčová K., Růžek D., Boura E., Nencka R. (2021) Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication Viruses-Basel 8: 1585.
DOI: 10.3390/v13081585
Eyer L., Svoboda P., Balvan J., Vičar T., Raudenská M., Štefánik M., Haviernik J., Huvarová I., Straková P., Rudolf I., Hubálek Z., Seley-Radtke K., De Clercq E., Růžek D. (2021) Broad-spectrum antiviral activity of 3′-Deoxy-3′-fluoroadenosine against emerging flaviviruses Antimicrobial Agents and Chemotherapy 65: e01522-20.
DOI: 10.1128/AAC.01522-20
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185: 104968.
DOI: 10.1016/j.antiviral.2020.104968
Milisavljevic N., Konkolová E., Kozák J., Hodek J., Veselovská L., Čížek K., Pohl R., Eyer L., Svoboda P., Růžek D., Weber J., Nencka R., Boura E., Hocek M. (2021) Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases 76: 471–478.
DOI: 10.1021/acsinfecdis.0c00829
Štefánik M., Straková P., Haviernik J., Miller A., Růžek D., Eyer L. (2021) Antiviral activity of vacuolar atpase blocker diphyllin against sars-cov-2 Microorganisms 9: 471.
DOI: 10.3390/microorganisms9030471
Gejji V. , Svoboda P., Štefánik M., Wang H., Salát J., Eyer L., Růžek D., Fernando S. (2020) An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus(Article) Virology 546: 13–19.
DOI: 10.1016/j.virol.2020.03.006
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185: 104968.
DOI: 10.1016/j.antiviral.2020.104968

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