HR Excellence in Science

prof. RNDr. Daniel Růžek, Ph.D.

Position Head of Laboratory - Laboratory of Arbovirology
Tick-Borne Diseases
Institute of Parasitology

Contact details +420 387775458
ruzekd@paru.cas.cz
316

Others

Research interests

  • virology: arboviruses, zoonoses, neurovirology

born 30. 4. 1981 in Jindřichův Hradec, Czechoslovakia

Education

  • 2013: Associate Professor (docent) in the field of Medical Microbiology, Faculty of Military Health Sciences, University of Defense, Hradec Králové, Czech Republic
  • 2005-2008: Ph.D.(Molecular and Cellular Biology and Genetics) Academy of Sciences of the Czech Republic, Institute of Parasitology, and University of South Bohemia, Faculty of Science
  • 2007: RNDr.(Advanced Master’s degree: “Rerum Naturalium Doctor” = Doctor of Natural Sciences; Clinical Biology) University of South Bohemia, Faculty of Biological Sciences
  • 2003-2005: MSc.(Clinical Biology; graduated with the highest honours), University of South Bohemia, Faculty of Biological Sciences
  • 2000-2003: BSc.(Biology – Biomedical Laboratory Techniques) University of South Bohemia, Faculty of Biological Sciences
  • 2000: High School graduation (Czech language and literature, German language, Biology, Chemistry; graduated with the highest honours), High School in Český Krumlov

Postgraduate Courses

  • 2014: Masaryk University in Brno, Basic skills for managers (qualification course)
  • 2013: Mendel University in Brno: Basic teaching skills in university education (qualification course)
  • 2012:  Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course)
  • 2011: British Society for Immunology Summer School 2011, Atlantic College, St. Donat’s Castle, Wales, United Kingdom (postgraduate course)
  • 2011:  Société de Pathologie Infectieuse de Langue Française, Grenoble, France: “Acute Infectious Encephalitis” (postgraduate course)
  • 2010: Rollins School of Public Health, Emory University, Atlanta, USA: “BSL-4 Science and Safety” (qualification course)

Employment

  • 2013-present:      Associate Professor, Department of Medical Biology, Faculty of Science, Universtity of South Bohemia, České Budějovice, Czech Republic
  • 2012-present:      Head of the Department of Virology, Head of the Research Group on Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic
  • 2011-present:      Research Scientist and Head of the Laboratory of Arbovirology, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2009-2011:            Postdoctoral Scientist, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2008-2009:            Postdoctoral Scientist, Texas Biomedical Research Institute, Department of Virology and Immunology, San Antonio, Texas, USA
  • 2008-2013:            Assistant Professor (Medical Virology), University of South Bohemia, Faculty of Science, Department of Medical Biology
  • 2005-2009:            Research Assistant, Institute of Parasitology, Academy of Sciences of the Czech Republic
  • 2004-2008:            Assistant, University of South Bohemia, Faculty of Biological Sciences, Department of Medical Biology

Research Internships

  • 2018-2019 (3 months): Laboratoy of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan (visiting reseach scholar)
  • 2011 (2 weeks):   Laboratory of Neurovirology and Inflammation Biology, Centre for Cellular and Molecular Biology, Hyderabad, India (visiting reseach scholar)
  • 2008-2009 (1 year):        Department of Virology and Immunology, Texas Biomedical Research Institute, San Antonio, USA (postdoctoral scientist)
  • 2008 (2 weeks):   Laboratoire de Physiopathologie de la Barriere Hemato-Encephalique, Faculté des Sciences Jean Perrin, Université d’Artois, Lens, France (student internship)
  • 2006 (2 weeks):   Royal (Dick) School of Veterinary Studies, Centre for Tropical Veterinary Medicine, University of Edinburgh, United Kingdom (student internship)

Professional Associations

  • Member of the Expert Committee for Biological Sciences of the Research, Development and Innovation Council, Office of the Government of the Czech Republic, 2014-2017 (in 2015, Chairman of the Committee)
  • National representative at the International Committee for Taxonomy of Viruses (ICTV)
  • Member of the International Scientific Working Group on Tick-borne Encephalitis
  • Member of the Scientific Committee of the Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic
  • Member of the Institutional Board, Veterinary Research Institute, Brno, Czech Republic
  • Member of the PhD Advisory Board in the field of Medical Microbiology and Immunology, and Pathology, Faculty of Medicine, Masaryk University in Brno, Czech Republic
  • Member of the PhD Advisory Board in the field of Microbiology, Faculty of Science, Masaryk University in Brno, Czech Republic
  • Member of the Czechoslovak Society for Microbiology
  • Member of the American Society for Microbiology
  • Member and Member of the Membership Review Committee, World Society of Virology
  • Editorial Board Member: World Journal of Virology (since 2010), Medical Virology (Russia) (Медицинская вирусология) (since 2013), Epidemiology and Vaccinal Prevention (Russia, since 2014), Clinical and Vaccine Immunology (since 2016), Scientific Reports (since 2017), Antiviral Chemistry and Chemotherapy, Acta Virologica (since 2017), Antiviral Research (since 2019)
  • Associate Editor for Ticks and Tick-borne Diseases (Elsevier; since 2017)
  • Guest Editor: Emerging Viruses Series, Antiviral Research (Elsevier)
  • Guest Editor: Czech and Slovak Virology, Acta Virologica

Honors

  • 2019:  Certificate of Appreciation by the Dean of the College of Veterinary Medicine, National Chung Hsing University in Taichung, Taiwan.
  • 2011: Travel Grant, Société de Pathologie Infectieuse de Langue Française, France
  • 2009: Sinnecker-Kunz Award for young researchers in the field of tick-borne pathogens (Weimar, Germany)
  • 2009: Memory Medal of the city Vyšší Brod (Czech Republic)
  • 2009:  Extraordinary Prize by the Dean for Excellent Scientific Results during Ph.D. Studies. Faculty of Science, University of South Bohemia
  • 2006:  1st Prize, Student Scientific Work 2006, Student Grant Agency of the Faculty of Biological Sciences, University of South Bohemia
  • 2006: Travel Grant for young researches, European Society for Clinical Virology (Birmingham, UK)
  • 2000: Special Award, Czech National Round of the Student Scientific Work 2000, Rožnov pod Radhoštem, Czech Republic
  • 2000: 1st Prize, Student Scientific Work 2000, South Bohemia Region, Czech Republic

Books

  • Růžek, D. et al. 2015. Klíšťová encefalitida (Tick-borne encephalitis), Grada Publ., Prague, 200 pp.
  • Růžek, D. (editor): 2011. Flavivirus Encephalitis. InTech Publ., Rijeka. 478 pp. (ISBN: 978-953-307-669-0)
  • Singh, S.K. & Růžek, D. (editors): 2013. Neuroviral Infections. General Principles and DNA Viruses. Taylor and Francis CRC Publ.,Boca Raton, 390 pp. (ISBN: 9781466567191)
  • Singh, S.K. & Růžek, D. (editors): 2013. Neuroviral Infections. RNA Viruses and Retroviruses. Taylor and Francis CRC Publ., Boca Raton, 519 pp. (ISBN: 9781466567207)
  • Singh, S.K. & Růžek, D. (editors): 2014. Viral hemorrhagic fevers. Taylor and Francis CRC Publ., Boca Raton, 596 pp. (ISBN: 143-988-429-3)

Book Chapters

  • Růžek, D., Tkachev, S.E., Yakimenko, V.V., Karan, L.S., Grubhoffer, L. Omsk hemorrhagic fever virus. In: Molecular detection of human viral pathogens, edited by: D. Liu; Taylor and Francis CRC Publ., Boca Raton, USA,231-239.
  • Donoso Mantke, O., Karan, L.S., Růžek, D. Tick-borne encephalitis viruses: a general overview. In: Flavivirus Encephalitis, edited by: Daniel Růžek; InTech, Rijeka,133-156.
  • Růžek, D., Bilski, B., Günther, G. Tick-borne encephalitis. In: Neuroviral Infections, edited by S.K. Singh and D. Růžek; Taylor and Francis CRC Publ., Boca Raton, 211-237.
  • Kilian, P., Danielová, V., Růžek, D. Bunyaviruses. In: Neuroviral Infections, edited by S.K. Singh and D. Růžek; Taylor and Francis CRC Publ., Boca Raton, 67-91.
  • Fajfr, M., Růžek, D. Laboratory diagnosis of viral hemorrhagic fever. In: Viral hemorrhagic fevers, edited by S.K. Singh and D. Růžek, Taylor and Francis CRC Publ., Boca Raton, 183-206.
  • Růžek, D., Yakimenko, V.V., Karan, S.K., Tkachev, S.E. Omsk hemorrhagic fever. In: Viral hemorrhagic fevers, edited by S.K. Singh and D. Růžek, Taylor and Francis CRC Publ., Boca Raton, 553-562.
  • Růžek, D., Holbrook, M.R., Yakimenko, V.V., Karan, S.K., Tkachev, S.E. Omsk hemorrhagic fever virus. In: Manual of security sensitive microbes and toxins, edited by D. Liu, Taylor and Francis CRC Press., Boca Raton, 193-200.
  • Růžek, D., Yoshii, K., Bloom, M. Gould, E.A. Tick-borne encephalitis virus – virology. In: Dobler G, Erber, W., Schmitt, H.J. Tick-borne encephalitis – an update. Global Health Press, Singapore, 2017.
  • Růžek, D., Yoshii, K., Bloom, M. Gould, E.A. Tick-borne encephalitis virus – virology. In: Dobler G, Erber, W., Bröker, M. Schmitt, H.J. (Eds.) The TBE Book. Second Edition. Global Health Press, Singapore, 2019. 19-41. ISBN: 978-981-14-0914-1.
  • Černý, J., Elsterová, J., Růžek, D., Grubhoffer, L. Vertebrate viruses in polar ecosystems. In: di Prisco G, Elster J, Huiskes A, Edwards H (editors): Life in Extreme Environments: Insights in Biological Capability. Cambridge University Press. in press.

5 most important impacted publications:

  • Füzik T, Formanová P, Růžek D, Yoshii K, Niedrig M, Plevka P. Structure of tick-borne encephalitis virus and its neutralization by a monoclonal antibody. Nature Communications 2018 Jan 30;9(1):436.
  • Růžek, D., Yakimenko, V.V., Karan, L.S., Tkachev, S.E. (2010). Omsk haemorrhagic fever. The Lancet 376(9758):2104-13.
  • Eyer L, Kondo H, Zouharova D, Hirano M, Valdés JJ, Muto M, Kastl T, Kobayashi S, Haviernik J, Igarashi M, Kariwa H, Vaculovicova M, Cerny J, Kizek R, Kröger A, Lienenklaus S, Dejmek M, Nencka R, Palus M, Salat J, De Clercq E, Yoshii K, Ruzek D. Escape of tick-borne flavivirus from 2' -C-methylated nucleoside antivirals is mediated by a single conservative mutation in NS5 that has a dramatic effect on viral fitness. Journal of Virology 2017 Aug 16. pii: JVI.01028-17. doi: 10.1128/JVI.01028-17. (Editors‘ Choice)
  • Eyer L, Nencka R, Huvarová I, Palus M, Joao Alves M, Gould EA, De Clercq E, Růžek D. Nucleoside Inhibitors of Zika Virus. Journal of Infectious Diseases 2016 Sep 1;214(5):707-11. (Editors Choice; Highly cited according to WoS)
  • Eyer L, Nougairède A, Uhlířová M, Driouich JS, Zouharová D, Valdés JJ, Haviernik J, Gould EA, De Clercq E, de Lamballerie X, Ruzek D. An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. Journal of Virology. 2019 Jul 30;93(16). pii: e00367-19. (Editors Choice)

Teaching Medical Virology
Faculty of Science, University of South Bohemia

Pathogenesis of Viral Infections
Faculty of Science, Masaryk University

Total found: 117 records
Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P., Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H., Elsterová J., Teislerová D., Chrdle A., Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J., Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine 218: e20210236.
DOI: 10.1084/jem.20210236
Beliavskaia A., Hönig V., Erhart J., Vyhlídalová T., Palus M., Černý J., Kozlova I., Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science 8: 659786.
DOI: 10.3389/fvets.2021.659786
Černý J., Elsterová J., Růžek D., Grubhoffer L. (2021) Vertebrate viruses in polar ecosystems. In: G. di Prisco, G.M.E. Howell, J. Elster, A.H.L. Huiskes (Eds.). Life in Extreme Environments: Insights in Biological Capability 126-147.
DOI: 9781108724203
de Gasparo R., Pedotti M., Simonelli L., Nickl P., Mueckschh F., Cassaniti I., Percivalle E., Lorenzi J.C.C., Mazzola F., Magrì D., Michalcikova T., Haviernik J., Hönig V., Mrazkova B., Polakova N., Fortova A., Tureckova J., Iatsiuk V., Di Girolamoa S., Palus M., Zudova D., Bednar P., Bukova I., Bianchini F., Mehni D., Nencka R., Straková P., Pavlis O., Rozman J., Gioria S., Sammartino J.C., Giardina F., Gaiarsak S., Hammarström Q.P., Barnes C.O., Bjorkmann P.J., Calzola L., Piralla A., Baldanti F., Nussenzweig M.C., Bieniasz P.D., Hatziioannouh T., Procházka J., Sedlacek R., Robbiani D.F., Růžek D., Varani L. (2021) Bispecific antibody neutralizes SARS-CoV-2 variants, protects mice from disease and prevents escape Nature 593: 424–428.
DOI: 10.1038/s41586-021-03461-y
Dejmek M., Konkolová E., Eyer L., Straková P., Svoboda P., Šála M., Krejčová K., Růžek D., Boura E., Nencka R. (2021) Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication Viruses-Basel 8: 1585.
DOI: 10.3390/v13081585
Eyer L., Svoboda P., Balvan J., Vičar T., Raudenská M., Štefánik M., Haviernik J., Huvarová I., Straková P., Rudolf I., Hubálek Z., Seley-Radtke K., De Clercq E., Růžek D. (2021) Broad-spectrum antiviral activity of 3′-Deoxy-3′-fluoroadenosine against emerging flaviviruses Antimicrobial Agents and Chemotherapy 65: e01522-20.
DOI: 10.1128/AAC.01522-20
Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E., Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research 185: 104968.
DOI: 10.1016/j.antiviral.2020.104968
Kohlmaier B., Schweintzger N.A., Sagmeister M.G., Kohlfürst D.S., Sonnleitner A., Leitner M., Berghold A., Schmiedberger E., Fazekas F., Pichler A., Rejc-Marko J., Růžek D., Dufkova L., Čejková D., Husa P., Pýchová M., Krbková L., Chmelík V., Štruncová V., Zavadska D., Karelis G., Mickiene A., Zajkowska J., Bogovič P., Strle F., Zenz W. (2021) Clinical Characteristics of Patients with Tick-Borne Encephalitis (TBE): A European Multicentre Study from 2010 to 2017 Microorganisms 9: 1420.
DOI: 10.3390/microorganisms9071420
Krbková L., Čapovová I., Homola L., Lindušková J., Salát J., Růžek D. (2021) Tick-borne encephalitis in an 8.5-month-old boy suspected of febrile seizures Microorganisms 9: 1425.
DOI: 10.3390/microorganisms9071425
Kříha M.F., Chrdle A., Růžek D., Chmelík V. (2021) What we know and still do not know about tick-borne encephalitis? / Co víme a stále nevíme o klíšťové encefalitidě? Epidemiologie, Mikrobiologie, Imunologie 70: 189–198.
Lesiczka P.M., Hrazdilová K., Majerová K., Fonville M., Sprong H., Hönig V., Hofmannová L., Papežík P. , Růžek D., Zurek L., Votýpka J., Modrý D. (2021) The Role of Peridomestic Animals in the Eco-Epidemiology of Anaplasma phagocytophilum Microbial Ecology 82: 602–612.
DOI: 10.1007/s00248-021-01704-z
Majerová K., Gutiérrez R., Fonville M., Hönig V., Papežík P. , Hofmannová L., Lesiczka P.M., Nachum-Biala Y., Růžek D., Sprong H., Harrus S., Modrý D., Votýpka J. (2021) Hedgehogs and Squirrels as Hosts of Zoonotic Bartonella Species Pathogens 10: 686.
DOI: 10.3390/pathogens10060686
Milisavljevic N., Konkolová E., Kozák J., Hodek J., Veselovská L., Čížek K., Pohl R., Eyer L., Svoboda P., Růžek D., Weber J., Nencka R., Boura E., Hocek M. (2021) Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases 76: 471–478.
DOI: 10.1021/acsinfecdis.0c00829
Modrý D., Hofmannová L., Papežík P. , Majerová K., Votýpka J., Hönig V., Růžek D., Hrazdilová K. (2021) Hepatozoon in Eurasian red squirrels Sciurus vulgaris, its taxonomic identity, and phylogenetic placement Parasitology Research 120: 2989-2993.
DOI: 10.1007/s00436-021-07229-1
Petry M., Palus M., Leitzen E., Mitterreiter J.G., Huang B., Kröger A., Verjans G.M.G.M., Baumgärtner W., Rimmelzwaan G.F., Růžek D., Osterhaus A., Prajeeth C.K. (2021) Immunity to TBEV related flaviviruses with reduced pathogenicity protects mice from disease but not from TBEV entry into the CNS Vaccines 9: 196.
DOI: 10.3390/vaccines9030196
Robbiani D.F., Růžek D. (2021) A dark side to NS1 antibodies? The Journal of Experimental Medicine 218: e20211348.
DOI: 10.1084/jem.20211348
Salát J., Huňady M., Schanilec P., Straková P., Štefánik M., Svoboda P., Strelcova L., Bojcukova J., Palus M., Růžek D. (2021) Experimental and natural infections of tick-borne encephalitis virus in dogs Viruses-Basel 13: 2039.
DOI: 10.3390/v13102039
Štefánik M., Straková P., Haviernik J., Miller A., Růžek D., Eyer L. (2021) Antiviral activity of vacuolar atpase blocker diphyllin against sars-cov-2 Microorganisms 9: 471.
DOI: 10.3390/microorganisms9030471
Tonk M. , Růžek D., Vilcinskas A. (2021) Compelling Evidence for the Activity of Antiviral Peptides against SARS-CoV-2 Viruses-Basel 13: 912.
DOI: 10.3390/v13050912
Duraisamy S., Bhosale D., Lipenska I., Huvarová I., Růžek D., Windisch M.P., Miller A. (2020) Advanced therapeutics, vaccinations, and precision medicine in the treatment and management of chronic Hepatitis B viral infections: where are we and where are we going? Viruses-Basel 12: 998.
DOI: 10.3390/v12090998

More publications

CONTACT

Biology Centre CAS
Branišovská 1160/31
370 05 České Budějovice
Data box: r84nds8

 

+420 387 775 111 (switchboard)
+420 387 775 051 (secretariat)
+420 778 468 552 (for media)

Staff search

Biologické centrum Google mapa

Login to the intranet

To log into the intranet enter your login details

×