RNDr. Luděk Eyer, Ph.D.
Vědecký pracovník - Laboratoř arbovirologie
Klíšťaty přenášené nemoci
Parazitologický ústav
+420 533331911
eyer@vri.cz
316
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Celkem nalezeno: 30 záznamů
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Eyer L., Seley-Radtke K.,
Růžek D. (2023) New directions in the experimental therapy of tick-borne encephalitis Antiviral Research
210: 105504.
DOI: 10.1016/j.antiviral.2022.105504 |
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Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B., Eyer L.,
Hönig V.,
Palus M.,
Růžek D.,
Vyhlídalová T.,
Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine
76: 103818.
DOI: 10.1016/j.ebiom.2022.103818 |
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Štefánik M., Bhosale D.,
Straková P.,
Haviernik J., Fojtikova M., Dufkova L., Huvarová I.,
Salát J.,
Růžek D., Miller A., Eyer L. (2022) Diphyllin Shows a Broad-Spectrum Antiviral Activity against Multiple Medically Important Enveloped RNA and DNA Viruses Viruses-Basel
14: 354.
DOI: 10.3390/v14020354 |
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Thames J.E., Eyer L., Seley-Radtke K. (2022) Small molecule-based inhibitors for treatment of tick-borne encephalitis virus infection: Nucleoside analogs and nonnucleoside antivirals, Chapter II. In: D.I. Osolodkin (Ed.), Annual Reports in Medicinal Chemistry, Medicinal Chemistry of Tick-Borne Encephalitis.
256: 58: 55-92.
DOI: 10.1016/bs.armc.2022.08.003 |
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Dejmek M., Konkolová E., Eyer L.,
Straková P.,
Svoboda P., Šála M., Krejčová K.,
Růžek D., Boura E., Nencka R. (2021) Non-Nucleotide RNA-Dependent RNA Polymerase Inhibitor That Blocks SARS-CoV-2 Replication Viruses-Basel
8: 1585.
DOI: 10.3390/v13081585 |
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Eyer L., Svoboda P., Balvan J., Vičar T., Raudenská M., Štefánik M., Haviernik J., Huvarová I., Straková P., Rudolf I., Hubálek Z., Seley-Radtke K., De Clercq E.,
Růžek D. (2021) Broad-spectrum antiviral activity of 3′-Deoxy-3′-fluoroadenosine against emerging flaviviruses Antimicrobial Agents and Chemotherapy
65: e01522-20.
DOI: 10.1128/AAC.01522-20 |
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Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J.,
Palus M., de Lamballerie X., Gould E.,
Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
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Milisavljevic N., Konkolová E., Kozák J., Hodek J., Veselovská L., Čížek K., Pohl R., Eyer L., Svoboda P.,
Růžek D., Weber J., Nencka R., Boura E., Hocek M. (2021) Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses. ACS Infectious Diseases
76: 471–478.
DOI: 10.1021/acsinfecdis.0c00829 |
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Štefánik M., Straková P., Haviernik J., Miller A.,
Růžek D., Eyer L. (2021) Antiviral activity of vacuolar atpase blocker diphyllin against sars-cov-2 Microorganisms
9: 471.
DOI: 10.3390/microorganisms9030471 |
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Gejji V. , Svoboda P., Štefánik M., Wang H., Salát J., Eyer L.,
Růžek D., Fernando S. (2020) An RNA-dependent RNA polymerase inhibitor for tick-borne encephalitis virus(Article) Virology
546: 13–19.
DOI: 10.1016/j.virol.2020.03.006 |
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Haviernik J., Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J.,
Palus M., de Lamballerie X., Gould E.,
Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
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Procházková E. , Hřebabecký H., Dejmek M., Šála M., Šmídková M., Tloušťová E., Zborníková E., Eyer L.,
Růžek D., Nencka R. (2020) Could 5 '-N and S ProTide analogues work as prodrugs of antiviral agents? Bioorganic&MedicinalChemistryLetters
30: 126897.
DOI: 10.1016/j.bmcl.2019.126897 |
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Salát J., Mikulášek K., Larralde O., Pokorná Formanová P., Chrdle A., Haviernik J.,
Elsterová J., Teislerová D.,
Palus M., Eyer L., Zdráhal Z., Petrik J.,
Růžek D. (2020) Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and may Elicit NS1-Specific Antibody Responses in Vaccinated Individuals. Vaccines
8: 81.
DOI: 10.3390/vaccines8010081 |
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Štefánik M.,
Valdés J. J., Ezebuo F.C., Haviernik J., Uzochukwu I.C., Fojtikova M., Salát J., Eyer L.,
Růžek D. (2020) FDA-Approved Drugs Efavirenz, Tipranavir, and Dasabuvir Inhibit Replication of Multiple Flaviviruses in Vero Cells Microorganisms
8: 599.
DOI: 10.3390/microorganisms8040599 |
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Eyer L., Fojtikova M., Nencka R., Rudolf I., Hubálek Z.,
Růžek D. (2019) Viral RNA-Dependent RNA Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Prevents Death in a Mouse Model of West Nile Virus Infection Antimicrobial Agents and Chemotherapy
63: e02093-18.
DOI: 10.1128/AAC.02093-18 |
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Eyer L., Nougairède A., Uhlířová M., Driouich J.S., Zouharova D.,
Valdés J. J., Haviernik J., Gould E., De Clercq E., de Lamballerie X.,
Růžek D. (2019) An E460D Substitution in the NS5 Protein of Tick-Borne Encephalitis Virus Confers Resistance to the Inhibitor Galidesivir (BCX4430) and Also Attenuates the Virus for Mice. Journal of Virology
93: pii: e00367-19.
DOI: 10.1128/JVI.00367-19 |
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Krol E., Wandzik I., Brzuska G., Eyer L.,
Růžek D., Szewczyk B. (2019) Antiviral Activity of Uridine Derivatives of 2-Deoxy Sugars against Tick-Borne Encephalitis Virus Molecules
24: 1129.
DOI: 10.3390/molecules24061129 |
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Růžek D., Avšič Županc T., Borde J., Chrdle A., Eyer L., Karganova G. , Kholodilov I., Knap N., Kozlovskya L., Matveev A., Miller A., Osoldkin D.I., Överby A.K., Titukonova N. , Tkachev S., Zajkowska J. (2019) Tick-borne encephalitis in Europe and Russia: Review of pathogenesis, clinical features, therapy, and vaccines Antiviral Research
164: 23–51.
DOI: 10.1016/j.antiviral.2019.01.014 |
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Eyer L., Nencka R., De Clercq E., Seley-Radtke K.,
Růžek D. (2018) Nucleoside analogs as a rich source of antiviral agents active against arthropod-borne flaviviruses. vAntiviral Chemistry and Chemotherapy
26: 1-28.
DOI: 10.1177/2040206618761299 |
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Haviernik J., Štefánik M., Fojtikova M., Kali S., Noël T., Rudolf I., Hubálek Z.,
Růžek D., Eyer L. (2018) Arbidol (Umifenovir): A Broad-Spectrum Antiviral Drug That Inhibits Medically Important Arthropod-Borne Flaviviruses. Viruses
10: 184.
DOI: 10.3390/v10040184 |
