HR Excellence in Science

Adrian-Stefan Andrei, Ph.D.

Kontaktní údaje 387775819


My research interests revolve around microbial ecology and biogeography. By making use of ecogenomics-based approaches, I am interested in exploring the basal foliage of the phylogenomic tree of life and unveiling the links between ecological and chemical diversity in aquatic ecosystems.

As life allegedly arose in aquatic environments more than 3.4 Ga ago and rapidly reached remarkable levels of metabolic sophistication, it freed itself from the anaerobiosis chains and triggered a series of events that culminated with the dawn of the Great Oxygenation Event. As aquatic environments represent Terra’s lifeblood and cover more than 70% of its surface (comprising its largest ecosystems and storing a substantial part of its biomass), the microorganisms harbored by them are of crucial importance for the sustainability and habitability of our planet, and represent the foundation of life as we know it. So far, despite their critical significance, little is known about the great extent of aquatic microbial diversity and its metabolic complexity. Furthermore, the vast majority of aquatic microorganisms cannot be axenically cultured and described under standard laboratory conditions, making their ecological functions and interactions largely uncharted. The ‘omics’-based approaches and sequencing technologies have revolutionized our way to scrutinize the microbial world and provided powerful tools to survey whole microbial communities, including their metabolic potential, evolutionary history, phylogeny and biogeography. In our technology-driven exploration of the microbial world, my (current) work seeks to make use of culture-free deep-sequencing and bioinformatics in order to shed light on the viral components of freshwater habitats and their elusive prokaryotic hosts.

Research gate profile:

Celkem nalezeno: 19 záznamů
Baricz A. , Chiriac C.M., Andrei A., Bulzu P.A., Levei E.A., Cadar O., Battes K.P., Cîmpean M. , Șenila M., Cristea A., Muntean V. , Alexe M. , Coman C., Szekeres E.K., Sicora C.I., Ionescu A., Blain D., Edwards J., Hallsworth J.E., Banciu H.L. (2021) Spatio-temporal insights into microbiology of the freshwater-to-hypersaline, oxic-hypoxic-euxinic waters of Ursu Lake. Environmental Microbiology 23: 3523–3540.
DOI: 10.1111/1462-2920.14909
Durán-Viseras A., Andrei A., Vera-Gargallo B., Ghai R., Sánchez-Porro C., Ventosa A. (2021) Culturomics-based genomics sheds light on the ecology of the new haloarchaeal genus Halosegnis. Environmental Microbiology 23: 3418–3434.
DOI: 10.1111/1462-2920.15082
Mujakic I., Andrei A., Shabarova T., Kolesár Fecskeová L., Salcher M., Piwosz K., Ghai R., Koblížek M. (2021) Common presence of phototrophic Gemmatimonadota in temperate freshwater lakes. mSystems 6: e01241-20.
DOI: 10.1128/mSystems.01241-20
Inoue K. , Tsunoda S.P., Singh M., Tomida S., Hososhima S., Konno M., Nakamura R., Watanabe H. , Bulzu P.A., Banciu H.L., Andrei A., Uchihashi T., Ghai R., Béjà O., Kandori H. (2020) Schizorhodopsins: A family of rhodopsins from Asgard archaea that function as light-driven inward H+ pumps Science Advances 6: eaaz2441.
DOI: 10.1126/sciadv.aaz2441
Mukherjee I., Salcher M., Andrei A., Kavagutti V., Shabarova T., Grujčić V., Haber M., Layoun P., Hodoki Y., Nakano S., Šimek K., Ghai R. (2020) A freshwater radiation of diplonemids Environmental Microbiology 22: 4658–4668.
Park S.J., Andrei A., Bulzu P., Kavagutti V., Ghai R., Mosier A.C. (2020) Expanded diversity and metabolic versatility of marine nitrite-oxidizing bacteria revealed by cultivation-and genomics-based approaches. Applied and Environmental Microbiology 86: e01667-20.
Remizovschi A. , Carpa R. , Forray F.L. , Chiriac C. , Roba C.A. , Beldean-Galea S. , Andrei A., Szekeres E. , Baricz A. , Lupan I., Knut R. , Coman C. (2020) Mud volcanoes and the presence of PAHs Scientific Reports 10: 1253.
DOI: 10.1038/s41598-020-58282-2
Salcher M., Andrei A., Bulzu P., Keresztes Z.G., Banciu H.L., Ghai R. (2020) Visualization of Lokiarchaeia and Heimdallarchaeia (Asgardarchaeota) by fluorescence in situ hybridization and catalyzed reporter deposition (CARD-FISH) mSphere 5: e00686-20.
Andrei A., Salcher M., Mehrshad M., Rychtecký P., Znachor P., Ghai R. (2019) Niche-directed evolution modulates genome architecture in freshwater Planctomycetes ISME Journal 13: 1056–1071.
DOI: 10.1038/s41396-018-0332-5
Bulzu P.A., Andrei A., Salcher M., Mehrshad M., Inoue K. , Kandori H. , Béjà O., Ghai R., Banciu H.L. (2019) Casting light on Asgardarchaeota metabolism in a sunlit microoxic niche Nature Microbiology 4: 1129–1137 .
DOI: 10.1038/s41564-019-0404-y
Durán-Viseras A., Andrei A., Ghai R., Sánchez-Porro C., Ventosa A. (2019) New Halonotius Species Provide Genomics-Based Insights Into Cobalamin Synthesis in Haloarchaea Frontiers in Microbiology 10: 1928.
DOI: 10.3389/fmicb.2019.01928
Kavagutti V., Andrei A., Mehrshad M., Salcher M., Ghai R. (2019) Phage-centric ecological interactions in aquatic ecosystems revealed through ultradeep metagenomics Microbiome 7: 135.
DOI: 10.1186/s40168-019-0752-0
Vavourakis C.D. , Mehrshad M., Balkema C., van Hall R., Andrei A., Ghai R., Sorokin D., Muyzer G. (2019) Metagenomes and metatranscriptomes shed new light on the microbial-mediated sulfur cycle in a Siberian soda lake BMC Biology 17: 69.
DOI: 10.1186/s12915-019-0688-7
Alexe M. , Şerban G., Baricz A. , Andrei A., Cristea A., Battes K.P., Cîmpean M. , Momeu L., Muntean V. , Porav S.A. , Banciu H.L. (2018) Limnology and plankton diversity of salt lakes from Transylvanian Basin (Romania): A review Journal of Limnology 77 : 17-34.
DOI: 10.4081/jlimnol.2017.1657
Cristea A., Baricz A, Leopold N., Floare C.G. , Borodi G. , Kacso I., Tripon S., Bulzu P.A., Andrei A., Cadar O., Levei E.A., Banciu H.L. (2018) Polyhydroxybutyrate production by an extremely halotolerant Halomonas elongata strain isolated from the hypersaline meromictic Fără Fund Lake (Transylvanian Basin, Romania) Journal of Applied Microbiology 125: 1343-1357.
DOI: 10.1111/jam.14029
Mehrshad M., Salcher M.M., Okazaki Y., Nakano S., Šimek K., Andrei A., Ghai R. (2018) Hidden in plain sight—highly abundant and diverse planktonic freshwater Chloroflexi Microbiome 6: 176.
DOI: 10.1186/s40168-018-0563-8
Vavourakis C.D. , Andrei A., Mehrshad M., Ghai R., Sorokyn D. Y., Muyzer G. (2018) A metagenomics roadmap to the uncultured genome diversity in hypersaline soda lake sediments Microbiome 6: 168.
DOI: 10.1186/s40168-018-0548-7
Andrei A., Baricz A. , Robeson M.S., Pǎuşan M.R., Tǎmaş T., Chiriac C., Szekeres E., Barbu-Tudoran L., Levei E.A., Coman C., Podar M., Banciu H.L. (2017) Hypersaline sapropels act as hotspots for microbial dark matter Scientific Reports 7: 6150.
DOI: 10.1038/s41598-017-06232-w
Andrei A., Pausan M.R., Tamas T., Har N., Barbu-Tudoran L., Leopold N., Banciu H.L. (2017) Diversity and biomineralization potential of the epilithic bacterial communities inhabiting the oldest public stone monument of Cluj-Napoca (Transylvania, Romania) Frontiers in Microbiology 8: 372.
DOI: 10.3389/fmicb.2017.00372


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