HR Excellence in Science

RNDr. Ondřej Hajdušek, Ph.D.

Position Research Scientist - Laboratory of Molecular Biology of Ticks
Biology of Disease Vectors
Institute of Parasitology

Contact details +420 387775496


Research interests

  • Vaccines against ticks and tick-transmitted diseases
  • Tick innate immunity

Key words: tick, Ixodes, Borrelia, Babesia, Anaplasma, iron, ferritin, innate immunity


  • Bachelor program - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Biology; Biomedicine laboratory technique)
  • Masters program  - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic (Parasitology)
  • Ph.D. program (graduated 2009) - University of South Bohemia in České Budějovice, Faculty of Science, Czech Republic (Parasitology)
  • Postdoctoral research - Institut de Biologie Moléculaire et Cellulaire (IBMC), CNRS UPR 9022 (Réponse immunitaire et développement chez les Insectes), Strasbourg, France (3 years)

Science visits:

  • 1998 -    PHLS London (UK) - science visit  (1 week)
  • 2001 -    University of Glasgow (UK) - Socrates Erasmus program (4 months)
  • 2005 -    National Research Council of Canada, Ottawa (CAN) - science visit (3 months)
  • 2006 -    Centre National de la Recherche Scientifique, Strasbourg (FRA) - science visit (2 months)


  • 2009 -    Dean´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Rector´s award - University of South Bohemia in České Budějovice, Faculty of Biological Sciences, Czech Republic
  • 2009 -    Scopus Young Researcher Award, Czech Republic


  • 2010-2012 -   EMBO Long Term Fellowship
  • 2013-2015 -   Grant agency of the Czech republic (GACR) - 13-27630P
  • 2013-2015 -   MODBIOLIN, 7FP, GA No. 316304
  • 2014-2018 -    ANTIDotE, 7FP EU
  • 2016-2019 -   Grant agency of the Czech republic (GACR) - 17-27386S

Total found: 39 records
Perner J., Hajdušek O., Kopáček P. (2022) Independent somatic distribution of heme and iron in ticks Current Opinion in Insect Science 51: 100916.
DOI: 10.1016/j.cois.2022.100916
Klouwens M.J., Trentelman J.J., Ersoz J.I., Nieves Marques Porto F., Šíma R., Hajdušek O., Thakur M., Hovius J. (2021) Investigating BB0405 as a novel Borrelia afzelii vaccination candidate in Lyme borreliosis Scientific Reports 11: 4775.
DOI: 10.1038/s41598-021-84130-y
Kotál J., Polderdijk S.G.I., Langhansová H., Ederová M., Martins L., Beránková Z., Chlastáková A., Hajdušek O., Kotsyfakis M., Huntington J.A., Chmelař J. (2021) Ixodes ricinus salivary serpin iripin-8 inhibits the intrinsic pathway of coagulation and complement International Journal of Molecular Sciences 22: 9480.
DOI: 10.3390/ijms22179480
Mahmood S., Šíma R., Urbanová V., Trentelman J.J., Krezdorn N., Winter P., Kopáček P., Hovius J., Hajdušek O. (2021) Identification of Tick Ixodes ricinus Midgut Genes Differentially Expressed During the Transmission of Borrelia afzelii Spirochetes Using a Transcriptomic Approach Frontiers in Immunology 11: 612412.
DOI: 10.3389/fimmu.2020.612412
Trentelman J., Tomás-Cortázar J., Knorr S. , Barriales D., Hajdušek O., Šíma R., Ersoz J.I., Narasimhan S., Fikrig E., Nijhof A., Anguita J., Hovius J. (2021) Probing an Ixodes ricinus salivary gland yeast surface display with tick-exposed human sera to identify novel candidates for an anti-tick vaccine Scientific Reports 11: 15745.
DOI: 10.1038/s41598-021-92538-9
Kamp H.D., Swanson K.A., Wei R.R., Dhal P.K., Dharanipragada R., Kern A., Sharma B., Šíma R., Hajdušek O., Hu L.T., Wei Ch.-J., Nabel G.J. (2020) Design of a broadly reactive Lyme disease vaccine npj Vaccines 5: 33.
DOI: 10.1038/s41541-020-0183-8
Mateos-Hernández L., Defaye B., Vancová M., Hajdušek O., Šíma R., Park Y., Attoui H., Šimo L. (2020) Cholinergic axons regulate type I acini in salivary glands of Ixodes ricinus and Ixodes scapularis ticks Scientific Reports 10: 16054.
DOI: 10.1038/s41598-020-73077-1
Trentelman J.J., Šíma R., Krezdorn N., Tomás-Cortázar J., Barriales D., Takumi K., Butler J.M., Sprong H., Klouwens M.J., Urbanová V., Mahmood S., Winter P., Kopáček P., Anguita J., Hajdušek O., Hovius J. (2020) A combined transcriptomic approach to identify candidates for an anti-tick vaccine blocking B. afzelii transmission Scientific Reports 10: 20061.
DOI: 10.1038/s41598-020-76268-y
Pospíšilová Pospíšilová, Urbanová V., Hes O., Kopáček P., Hajdušek O., Šíma R. (2019) Tracking of Borrelia afzelii transmission from infected Ixodes ricinus nymphs to mice Infection and Immunity 87: e00896-18.
DOI: 10.1128/IAI.00896-18
Rego R. O. M., Trentelman J.J., Anguita J., Nijhof A., Sprong H., Klempa B., Hajdušek O., Tomás-Corázar J., Azagi T., Strnad M., Knorr S. , Šíma R., Jalovecká M., Havlíková S., Ličková M., Sláviková M., Kopáček P., Grubhoffer L., Hovius J. (2019) Counterattacking the tick bite: towards a rational design of anti-tick vaccines targeting pathogen transmission Parasites & Vectors 12: 229.
DOI: 10.1186/s13071-019-3468-x
Jalovecká M., Hajdušek O., Sojka D., Kopáček P., Malandrin L. (2018) The Complexity of Piroplasms Life Cycles Frontiers in Cellular and Infection Microbiology 8: 248.
DOI: 10.3389/fcimb.2018.00248
Jalovecká M., Hartmann D., Miyamoto Y., Eckmann L. , Hajdušek O., O´Donoghue A.J. , Sojka D. (2018) Validation of Babesia proteasome as a drug target International Journal for Parasitology-Drugs and Drug Resistance 8: 394–402.
DOI: 10.1016/j.ijpddr.2018.08.001
Knorr S. , Anguita J., Cortazar J.T., Hajdušek O., Kopáček P., Trentelman J.J., Kershaw O., Hovius J., Nijhof A. (2018) Preliminary Evaluation of Tick Protein Extracts and Recombinant Ferritin 2 as Anti-tick Vaccines Targeting Ixodes ricinus in Cattle. Frontiers in Physiology 9: 1969.
DOI: 10.3389/fphys.2018.01696
Kopáček P., Perner J., Sojka D., Šíma R., Hajdušek O. (2018) Molecular Targets to Impair Blood Meal Processing in Ticks. In: Ch. Q. Meng, A. E. Sluder and P.M Selzer (Eds.), Ectoparasites: Drug Discovery Against Moving Targets Wiley 139–165.
DOI: 10.1002/9783527802883
Urbanová V., Hajdušek O., Šíma R., Franta Z., Grunclová L., Hönig Mondeková H., Bartošová-Sojková P., Jalovecká M., Kopáček P. (2018) IrC2/Bf e A yeast and Borrelia responsive component of the complement system from the hard tick Ixodes ricinus Developmental and Comparative Immunology 79: 86-94.
DOI: 10.1016/j.dci.2017.10.012
Hönig Mondeková H., Šíma R., Urbanová V., Kovář V., Rego R. O. M., Grubhoffer L., Kopáček P., Hajdušek O. (2017) Characterization of Ixodes ricinus Fibrinogen-Related Proteins (Ixoderins) Discloses Their Function in the Tick Innate Immunity Frontiers in Cellular and Infection Microbiology 7: 509.
DOI: 10.3389/fcimb.2017.00509
Panetta J.L., Šíma R., Calvani N.E.D., Hajdušek O., Chandra S., Panuccio J., Šlapeta J. (2017) Reptile-associated Borrelia species in the goanna tick (Bothriocroton undatum) from Sydney, Australia Parasites & Vectors 10: 616.
DOI: 10.1186/s13071-017-2579-5
Urbanová V., Hajdušek O., Hönig Mondeková H., Šíma R., Kopáček P. (2017) Tick Thioester-Containing Proteins and Phagocytosis Do Not Affect Transmission of Borrelia afzelii from the Competent Vector Ixodes ricinus Frontiers in Cellular and Infection Microbiology 7: 73.
DOI: 10.3389/fcimb.2017.00073
Aase A., Hajdušek O., Øines Ø., Quarsten H., Wilhelmsson P., Herstad T., Kjelland V., Šíma R., Jalovecká M., Lindgren P., Aaberg I. (2016) Validate or falsify: Lessons learned from a microscopy method claimed to be useful for detecting Borrelia and Babesia organisms in human blood Infectious Diseases 48: 411-419.
DOI: 10.3109/23744235.2016.1144931
Hajdušek O., Šíma R., Perner J., Loosová G., Harcubová A., Kopáček P. (2016) Tick iron and heme metabolism - New target for an anti-tick intervention Ticks and tick-borne diseases 7: 565-572.
DOI: 10.1016/j.ttbdis.2016.01.006

More publications


Biology Centre CAS
Branišovská 1160/31
370 05 České Budějovice
Data box: r84nds8


+420 387 775 111 (switchboard)
+420 387 775 051 (secretariat)
+420 778 468 552 (for media)

Staff search

Biologické centrum Google mapa

Login to the intranet

To log into the intranet enter your login details