RNDr. Martin Palus, Ph.D.
Head of Laboratory - Laboratory of Arbovirology
Tick-Borne Diseases
Institute of Parasitology
+420 387775145
palus@paru.cas.cz
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The researcher is interested in the study of human viral infections and the possibilities of their treatment. The main interest is tick-borne encephalitis virus and related viruses transmitted by ticks and mosquitoes (Zika virus, West Nile fever, Chikungunya virus, Usutu virus, hemorrhagic fever viruses,...), but also other viruses that require attention, such as SARS-CoV2. Specifically, for example, the study of the interactions of tick-borne encephalitis virus with the blood-brain barrier, neuronal damage, the inflammatory response triggered by the virus (immunopathology), antibody therapy,... Education Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic 2012-2016 Ph.D. (hons.) Infectious Biology Tick-borne encephalitis – from pathogenesis to therapy 2015 RNDr. Clinical Biology Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system 2009-2012 MSc. Clinical Biology The role of the host genetic background on the pathogenesis of tick-borne encephalitis 2007-2009 2006-2009 BSc. (hons.) Biology Biology-Biomedical Laboratory Techniques Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background Employment 2014-present: Researcher Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic 2011-present: Head of Lab Laboratory of Arbovirology Institute of Parasitology, Biology Centre, Czech Academy of the Sciences 2011-2012: Assistant Laboratory of Biological Monitoring and Protection, The National Institute for Nuclear, Chemical and Biological Protection, Czech Republic 2009: Assistant Dept. of Parasite Immunology , Institute of Parasitology, Biology Centre, Czech Academy of the Sciences Research Funding (PI) 2020: Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tick-borne encephalitis; The Czech Science Foundation (GACR); 8 426 thousands of CZK; (2020 - 2022) 2020: Identification and characterization of TBEV-neutralizing and cross-reactive antibodies from individuals that are convalescent from flaviviral infection; Programme for research and mobility support of starting researchers from Czech Academy of Sciences (2020-2021) 2017: Programme of Support of Postdoctoral Fellowships from Czech Academy of Sciences (2017-2018) 2015: Role of the human brain microvascular endothelial cells during tick-borne encephalitis virus infection in the central nervous system; Grant Agency of the University of South Bohemia 2014: Role of the human non-neural cells in the neuronal injury during tick-borne encephalitis; Grant Agency of the University of South Bohemia in Ceske Budejovice Postgraduate Courses and Internships 2020-2021: Internship: Immunology and Infectious Disease (Davide Robbiani), Institute for Research in Biomedicine, Switzerland 2014: PREDEMICS, National Institute for Infectious Diseases “L. Spallanzani” – Rome: Workshop on zoonotic features of viral infections from the animal reservoir to pandemic emergence 2012: Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course) 2011: Erasmus Programme: Arbovirus Pathogenesis Group, The Roslin Institute and Royal (Dick)School of Veterinary Studies, The University of Edinburgh (4 mos.) Honors 2021: Prize by the President of Czech Academy of Sciences for young scientists for outstanding results 2018: Otto Wichterle's Award for selected, exceptionally high-quality and promising scientists from the Czech Academy of Sciences 2017: Dean’s Award for excellent scientific results during Ph.D. studies. Faculty of Science, University of South Bohemia 2015: Award for the best Czech and Slovak young microbiologist of the year (Czechoslovak Society for Microbiology; XXIV. Tomasek Days of young microbiologists, Brno) 2013: Best poster award (Moscow, “Chumakov IPVE” RAMS, Up-to-date problems of TBE) Publications ORCID ID: 0000-0002-4279-7092 WoS RID: N-1263-2017 Scopus Author ID=25825507600 Selected conferences contribution (talk/poster) 2019: 22nd International Symposium on Signal Transduction at The Blood-Brain Barriers, Germany, Würzburg 2019: The 67th Annual Meeting of the Japanese Society for Virology, Japan, Tokyo 2019: Joint CzechoSlovak Virology Conference 2019 and 1st SK-AT Structural Virology Meeting, Bratislava 2018: 21nd International Symposium on Signal Transduction at the Blood Brain Barriers, Romania, Arad 2018: 28. Pečenkovy epidemiologické dny, České Budějovice 2017: Tick and Tick-borne Pathogens 9 (One Health), Australia, Cairns 2017: Joint CzechoSlovak Virology Conference 2017, České Budějovice 2015: International Symposium on Flaviviruses: Structure and Immunity, Austria, Vienna Selected applied research Prototype 2021: HL1/FZU/2021: Antifouling biochip surface based on terpolymer specific antibody-postmodified layer for rapid detection of SARS-CoV-2 virus by means of quartz crystal microbalance (QCM) method Prototype 2021: Methodological platform for rapid detection of SARS-CoV-2 based on loop mediated isothermal amplification Prototype 2020: HL1/FZU/2020: Functional biochip based on ultra-low fouling polymer for rapid detection of SARS-COV-2 virus in crude biological fluids Other Member of the Czechoslovak Society for Microbiology Certificate for the performance of diagnostic methods and preparation of medications (Institute for Postgraduate education in Medicine, Prague) Certificate of competency according to § 15d of the Act No. 246/1992 coll. on Protection Animals against Cruelty in present statues at large. Czech University of Life Sciences in Prague, Central commission for Animal Welfare (CCAW)Research interests
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Total found: 39 records
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Bianchini F., Crivelli V., Abernathy M.E., Guerra C., Palus M., Muri J., Marcotte H., Piralla A., Pedotti M. , de Gasparo R., Simonelli L., Matkovic M., Toscano C., Biggiogero M., Calvaruso V.,
Svoboda P., Cervantes Rincón T., Fava T., Podešvová L., Shanbhag A.A., Celoria A., Sgrignani J., Štefánik M.,
Hönig V.,
Prančlová V., Michalcikova T., Procházka J., Guerrini G., Mehn D., Ciabattini A., Abolhassani H., Jarrossay D., Uguccioni M., Medaglini D., Pan-Hammarström Q., Calzolai L., Fernandez D. , Baldanti F., Franzetti-Pellanda A., Garzoni C., Sedlacek R.,
Růžek D., Varani L., Cavalli A., Barnes C.O., Robbiani D.F. (2023) Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein Science Immunology
8: eade0958.
DOI: 10.1126/sciimmunol.ade0958 |
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Fořtová A.,
Hönig V.,
Salát J., Palus M., Pýchová M., Krbková L., Barkhash A.V., Kříha M.F., Chrdle A., Lipoldová M.,
Růžek D. (2023) Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients Virus Research
324: 199020.
DOI: 10.1016/j.virusres.2022.199020 |
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Kevély Á.,
Prančlová V., Sláviková M.,
Haviernik J.,
Hönig V., Nováková E., Palus M.,
Růžek D., Klempa B., Koči J. (2023) Fitness of mCherry reporter tick-borne encephalitis virus in tick experimental models Viruses-Basel
14: 2673.
DOI: 10.3390/v14122673 |
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Ribeiro J.,
Hartmann D.,
Bartošová-Sojková P., Debat H.,
Moos M., Fara J.,
Šimek P., Palus M.,
Kučera M.,
Hajdušek O.,
Sojka D.,
Kopáček P.,
Perner J. (2023) Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq Communications Biology
6: 517.
DOI: 10.1038/s42003-023-04907-x |
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Fořtová A.,
Hönig V., Palus M.,
Salát J., Pýchová M., Krbková L.,
Vyhlídalová T., Kříha M.F., Chrdle A.,
Růžek D. (2022) Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis Journal of General Virology
103: 1743.
DOI: 10.1099/jgv.0.001743 |
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Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B.,
Eyer L.,
Hönig V., Palus M.,
Růžek D.,
Vyhlídalová T.,
Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine
76: 103818.
DOI: 10.1016/j.ebiom.2022.103818 |
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Migné C.V.,
Hönig V., Bonnet S.I., Palus M., Rakotobe S., Galon C., Heckmann A.,
Výletová E., Devillers E., Attoui H.,
Růžek D., Moutailler S. (2022) Evaluation of two artificial infection methods of live ticks as tools for studying interactions between tick-borne viruses and their tick vectors Scientific Reports
12: 491.
DOI: 10.1038/s41598-021-04498-9 |
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Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P.,
Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H.,
Elsterová J., Teislerová D., Chrdle A.,
Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J.,
Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine
218: e20210236.
DOI: 10.1084/jem.20210236 |
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Beliavskaia A.,
Hönig V.,
Erhart J.,
Vyhlídalová T., Palus M., Černý J., Kozlova I.,
Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science
8: 659786.
DOI: 10.3389/fvets.2021.659786 |
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de Gasparo R., Pedotti M., Simonelli L., Nickl P., Mueckschh F., Cassaniti I., Percivalle E., Lorenzi J.C.C., Mazzola F., Magrì D., Michalcikova T.,
Haviernik J.,
Hönig V., Mrazkova B., Polakova N., Fortova A., Tureckova J., Iatsiuk V., Di Girolamoa S., Palus M., Zudova D., Bednar P., Bukova I., Bianchini F., Mehni D., Nencka R.,
Straková P., Pavlis O., Rozman J., Gioria S., Sammartino J.C., Giardina F., Gaiarsak S., Hammarström Q.P., Barnes C.O., Bjorkmann P.J., Calzola L., Piralla A., Baldanti F., Nussenzweig M.C., Bieniasz P.D., Hatziioannouh T., Procházka J., Sedlacek R., Robbiani D.F.,
Růžek D., Varani L. (2021) Bispecific antibody neutralizes SARS-CoV-2 variants, protects mice from disease and prevents escape Nature
593: 424–428.
DOI: 10.1038/s41586-021-03461-y |
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Forinová M., Pilipenco A., Víšová I., Lynn N.S., Dostálek J.,
Mašková H.,
Hönig V., Palus M.,
Selinger M., Kočová P., Dycka F., Štěrba J., Houska M., Vrabcová M., Horak P., Anthi J., Tung C.P., Yu C.M., Chen C.Y., Huang Y.C., Tsai P.H., Lin S.Y., Hsu H.J., Yang A.S., Dejneka A., Vaisocherová-Lísalová H. (2021) Functionalized terpolymer-brush-based biointerface with improved antifouling properties for ultra-sensitive direct detection of virus in crude clinical samples ACS Applied Materials and Interfaces
50: 60612–60624.
DOI: 10.1021/acsami.1c16930 |
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Haviernik J.,
Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E.,
Růžek D. (2021) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: A new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
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Petry M., Palus M., Leitzen E., Mitterreiter J.G., Huang B., Kröger A., Verjans G.M.G.M., Baumgärtner W., Rimmelzwaan G.F.,
Růžek D., Osterhaus A., Prajeeth C.K. (2021) Immunity to TBEV related flaviviruses with reduced pathogenicity protects mice from disease but not from TBEV entry into the CNS Vaccines
9: 196.
DOI: 10.3390/vaccines9030196 |
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Salát J., Huňady M., Schanilec P.,
Straková P., Štefánik M.,
Svoboda P., Strelcova L., Bojcukova J., Palus M.,
Růžek D. (2021) Experimental and natural infections of tick-borne encephalitis virus in dogs Viruses-Basel
13: 2039.
DOI: 10.3390/v13102039 |
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Haviernik J.,
Eyer L., Yoshii K., Kobayashi S., Černý J., Nougairède A., Driouich J.S., Volf J., Palus M., de Lamballerie X., Gould E.,
Růžek D. (2020) Development and characterization of recombinant tick-borne encephalitis virus expressing mCherry reporter protein: a new tool for high-throughput screening of antiviral compounds, and neutralizing antibody assays Antiviral Research
185: 104968.
DOI: 10.1016/j.antiviral.2020.104968 |
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Helmová R.,
Hönig V.,
Tykalová H., Palus M., Bell-Sakyi L.,
Grubhoffer L. (2020) Tick-borne encephalitis virus adaptation in different host environments and existence of quasispecies Viruses
12: 902.
DOI: 10.3390/v12080902 |
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Lattová E., Straková P., Pokorná Formanová P.,
Grubhoffer L., Bell-Sakyi L., Zdráhal Z., Palus M.,
Růžek D. (2020) Comprehensive N-glycosylation mapping of envelope glycoprotein from tick-borne encephalitis virus grown in human and tick cells Scientific Reports
10: 13204.
DOI: 10.1038/s41598-020-70082-2 |
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Salát J., Mikulášek K., Larralde O., Pokorná Formanová P., Chrdle A., Haviernik J.,
Elsterová J., Teislerová D., Palus M.,
Eyer L., Zdráhal Z., Petrik J.,
Růžek D. (2020) Tick-Borne Encephalitis Virus Vaccines Contain Non-Structural Protein 1 Antigen and may Elicit NS1-Specific Antibody Responses in Vaccinated Individuals. Vaccines
8: 81.
DOI: 10.3390/vaccines8010081 |
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Dufková P., Širmarová J.,
Salát J.,
Hönig V., Palus M.,
Růžek D., Fooks A., Mansfield K.L., Tordo N., Jochmans D., Neyts J., Byron M., Koraka P., Osterhaus A.D.M.E., Asklepios consortium (2019) Mannitol treatment is not effective in therapy of rabies virus infection in mice Vaccine
37: 4710–4714.
DOI: 10.1016/j.vaccine.2017.12.028 |
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Hönig V., Palus M., Kašpar T.,
Majerová K.,
Zemanová M., Hofmannová L., Papežík P. , Šikutová S., Rettich F., Hubálek Z., Rudolf I.,
Votýpka J.,
Modrý D.,
Růžek D. (2019) Multiple Lineages of Usutu Virus (Flaviviridae, Flavivirus) in Blackbirds (Turdus merula) and Mosquitoes (Culex pipiens, Cx. modestus) in the Czech Republic (2016–2019) Microorganisms
7: 568.
DOI: 10.3390/microorganisms7110568 Documents to download: Honig_2019_Microorganisms (pdf) |
