RNDr. Martin Palus, Ph.D.
Head of Laboratory - Laboratory of Arbovirology
Disease Vectors and Pathogens
Institute of Parasitology
+420 387775145
palus@paru.cas.cz
313c/324
My research activity is the study of human viral infections, disease development and its treatment options. Interest is focused on tick-borne encephalitis virus and related viruses transmitted by ticks and mosquitoes, as well as other viruses that require attention, such as SARS-CoV2. Education Faculty of Science, University of South Bohemia in Ceske Budejovice, Czech Republic 2012-2016 Ph.D. (hons.) Infectious Biology Tick-borne encephalitis – from pathogenesis to therapy 2015 RNDr. Clinical Biology Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system 2009-2012 MSc. Clinical Biology The role of the host genetic background on the pathogenesis of tick-borne encephalitis 2007-2009 2006-2009 BSc. (hons.) Biology Biology-Biomedical Laboratory Techniques Study of the pathogenesis of tick-borne encephalitis in hosts with different genetic and immunological background Employment 2014-present: Researcher Emerging Viral Diseases, Veterinary Research Institute, Brno, Czech Republic 2011-present: Head of Lab Laboratory of Arbovirology Institute of Parasitology, Biology Centre, Czech Academy of the Sciences 2011-2012: Assistant Laboratory of Biological Monitoring and Protection, The National Institute for Nuclear, Chemical and Biological Protection, Czech Republic 2009: Assistant Dept. of Parasite Immunology , Institute of Parasitology, Biology Centre, Czech Academy of the Sciences Research Funding (PI) 2023 Neuropathogenesis linked to NS1 protein of tick-borne encephalitis virus; The Czech Science Foundation (GACR); (2023 - 2025) 2022 Verification of the possibility of using a mouse antibody against the protein of the tick-borne encephalitis virus for the purposes of diagnosis of tick-borne encephalitis by the ELISA method; Technology Agency of the Czech Republic GAMA2; 2020: Neurovascular unit cells interactions leading to the blood-brain barrier breakdown during tick-borne encephalitis; The Czech Science Foundation (GACR); (2020 - 2022) 2020: Identification and characterization of TBEV-neutralizing and cross-reactive antibodies from individuals that are convalescent from flaviviral infection; Programme for research and mobility support of starting researchers from Czech Academy of Sciences (2020-2021) 2017: Programme of Support of Postdoctoral Fellowships from Czech Academy of Sciences (2017-2018) 2015: Role of the human brain microvascular endothelial cells during tick-borne encephalitis virus infection in the central nervous system; Grant Agency of the University of South Bohemia 2014: Role of the human non-neural cells in the neuronal injury during tick-borne encephalitis; Grant Agency of the University of South Bohemia in Ceske Budejovice Postgraduate Courses and Internships 2020-2021: Internship: Immunology and Infectious Disease (Davide Robbiani), Institute for Research in Biomedicine, Switzerland 2014: PREDEMICS, National Institute for Infectious Diseases “L. Spallanzani” – Rome: Workshop on zoonotic features of viral infections from the animal reservoir to pandemic emergence 2012: Institute of Postgraduate Education in Medicine in Prague: Methods in Laboratory Medicine (accredited qualification course) 2011: Erasmus Programme: Arbovirus Pathogenesis Group, The Roslin Institute and Royal (Dick)School of Veterinary Studies, The University of Edinburgh (4 mos.) Honors 2021: Prize by the President of Czech Academy of Sciences for young scientists for outstanding results 2018: Otto Wichterle's Award for selected, exceptionally high-quality and promising scientists from the Czech Academy of Sciences 2017: Dean’s Award for excellent scientific results during Ph.D. studies. Faculty of Science, University of South Bohemia 2015: Award for the best Czech and Slovak young microbiologist of the year (Czechoslovak Society for Microbiology; XXIV. Tomasek Days of young microbiologists, Brno) 2013: Best poster award (Moscow, “Chumakov IPVE” RAMS, Up-to-date problems of TBE) Publications ORCID ID: 0000-0002-4279-7092 WoS RID: N-1263-2017 Scopus Author ID=25825507600 Selected conferences contribution (talk/poster) 2023 15th International Symposium on Ticks and Tick-borne Diseases; Germany, Weimar (invited) 2022 10th Tick and Tick-Borne Pathogen Conference, Murighiol, Romania 2022 Konference: Národní institut virologie a bakteriologie, Czech Republic, Kutná Hora 2022 XXIV. Hradecké virologické dny, Czech Republic, Hradec Králové 2022 24th International Symposium on Signal Transduction at the Blood-Brain Barriers, Bari, Italy 2019: 22nd International Symposium on Signal Transduction at The Blood-Brain Barriers, Germany, Würzburg 2019: The 67th Annual Meeting of the Japanese Society for Virology, Japan, Tokyo 2019: Joint CzechoSlovak Virology Conference 2019 and 1st SK-AT Structural Virology Meeting, Bratislava 2018: 21nd International Symposium on Signal Transduction at the Blood Brain Barriers, Romania, Arad 2018: 28. Pečenkovy epidemiologické dny, České Budějovice 2017: Tick and Tick-borne Pathogens 9 (One Health), Australia, Cairns 2017: Joint CzechoSlovak Virology Conference 2017, České Budějovice 2015: International Symposium on Flaviviruses: Structure and Immunity, Austria, Vienna Selected applied research 0550809 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Antifoulingový povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro kvantitativní stanovení viru SARS-CoV-2 v klinických vzorcích pomocí metody QCM. 0555327 - BC 2022 RIV cze P1 - Užitný vzor, průmyslový vzor Sada primerů pro amplifikační kontrolu pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP a kit pro detekci koronaviru SARS-CoV-2 metodou izotermické amplifikace LAMP. 0542199 - FZÚ 2022 RIV CZ cze L - Prototyp, funkční vzorek Ultra-rezistentní povrch biočipu s terpolymerní vrstvou postmodifikovanou specifickou protilátkou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM. 0537039 - FZÚ 2021 RIV CZ cze L - Prototyp, funkční vzorek Funkční biočip s ultra-rezistentní polymerní vrstvou pro rychlou detekci viru SARS-CoV-2 pomocí metody QCM. O - Ostatní výsledky, 2015, Detection of tick-borne encephalitis virus subtypes by RT-qPCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra O - Ostatní výsledky, 2015, Virus Serotyping by TaqMan and SYTO 9 in Single Reaction; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra O - Ostatní výsledky, 2014, Flavivirus Detection by Quantitative PCR; Předkladatel: Státní ústav jaderné, chemické a biologické ochrany, v.v.i., Dodavatel: MV0 - Ministerstvo vnitra Other Member of the International Brain Barriers Society (IBBS) Member of the World Society for Virology (WSV) Member of the Czechoslovak Society for Microbiology Member of the Scientific Council of Institute of Parasitology, Biology Centre CAS Certificate for the sex and gender dimension of biomedical research completed Libra course Certificate for the performance of diagnostic methods and preparation of medications (Institute for Postgraduate education in Medicine, Prague) Certificate of competency according to § 15d of the Act No. 246/1992 coll. on Protection Animals against Cruelty in present statues at large. Czech University of Life Sciences in Prague, Central commission for Animal Welfare (CCAW)Research interests
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Total found: 50 records
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Beránková M.,
Holoubek J.,
Hönig V., Matúšová Z., Palus M.,
Salát J., Krayem I., Vojtíšková J. , Svoboda P.,
Prančlová V., Valihrach L., Demant P., Lipoldová M.,
Růžek D. (2025) Genotype-driven sensitivity of mice to tick-borne encephalitis virus correlates with differential host responses in peripheral macrophages and brain Journal of Neuroinflammation
22: 22.
DOI: 10.1186/s12974-025-03354-1 |
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Kříha M.,
Kamiš J.,
Dvořáková M.,
Tardy L.,
Elsterová J., Teislerová D., Chrdle A., Palus M.,
Růžek D.,
Hönig V. (2025) Detection of tick-borne encephalitis virus RNA in patient samples at different stages of infection. Journal of Infection
90: 106481.
DOI: 10.1016/j.jinf.2025.106481 |
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Kulmann M.I.R., Taborska E., Benköova B., Palus M., Drobek A., Horvat F., Pasulka J., Malik R., Salyova E.,
Hönig V., Pellerova M., Borsanyiova M.,
Nedvědová L., Štěpánek O., Bopegamage S.,
Růžek D., Svoboda P. (2025) Enhanced RNAi does not provide efficient innate antiviral immunity in mice Nucleic Acids Research
53: gkae1288.
DOI: 10.1093/nar/gkae1288 |
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Langhansová H., Beránková Z., Khanna R., Kotál J., Kotsyfakis M., Palus M.,
Lieskovská J. (2025) Tick salivary cystatin Iristatin limits the virus replication in skin of tick-borne encephalitis virus-infected mice Parasitology Research
124: 8.
DOI: 10.1007/s00436-024-08441-5 |
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Majstorović J.,
Arakelyan A., Trumbić Ž.,
Kamiš J., Adamek M., Rončević T., Čikeš Čulić V.,
Kyslík J., Palus M.,
Fiala I.,
Mladineo I. (2025) Cecropin anisaxin-2S has in vitro immunomodulatory, but not antiproliferative and antiviral propertie. Frontiers in Immunology
16: 1567505.
DOI: 10.3389/fimmu.2025.1567505 |
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Prančlová V.,
Hönig V.,
Zemanová M.,
Růžek D., Palus M. (2024) Robust CXCL10/IP-10 and CCL5/RANTES production induced by tick-borne Encephalitis virus in human brain pericytes despite weak infection International Journal of Molecular Sciences
25: 7892.
DOI: 10.3390/ijms25147892 |
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Prančlová V.,
Nedvědová L.,
Kotounová E.,
Hönig V.,
Dvořáková M.,
Davídková M.,
Bílý T.,
Vancová M.,
Růžek D., Palus M. (2024) Unraveling the role of human microglia in tick-borne encephalitis virus infection: insights into neuroinflammation and viral pathogenesis Microbes and Infection
26: 105383.
DOI: 10.1016/j.micinf.2024.105383 |
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Bianchini F., Crivelli V., Abernathy M.E., Guerra C., Palus M., Muri J., Marcotte H., Piralla A., Pedotti M. , de Gasparo R., Simonelli L., Matkovic M., Toscano C., Biggiogero M., Calvaruso V.,
Svoboda P., Cervantes Rincón T., Fava T., Podešvová L., Shanbhag A.A., Celoria A., Sgrignani J., Štefánik M.,
Hönig V.,
Prančlová V., Michalcikova T., Procházka J., Guerrini G., Mehn D., Ciabattini A., Abolhassani H., Jarrossay D., Uguccioni M., Medaglini D., Pan-Hammarström Q., Calzolai L., Fernandez D. , Baldanti F., Franzetti-Pellanda A., Garzoni C., Sedlacek R.,
Růžek D., Varani L., Cavalli A., Barnes C.O., Robbiani D.F. (2023) Human neutralizing antibodies to cold linear epitopes and subdomain 1 of the SARS-CoV-2 spike glycoprotein Science Immunology
8: eade0958.
DOI: 10.1126/sciimmunol.ade0958 |
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Fořtová A., Barkhash A.V., Pýchová M., Krbková L., Palus M.,
Salát J.,
Růžek D. (2023) Genetic polymorphisms in innate immunity genes influence predisposition to tick-borne encephalitis Journal of NeuroVirology
29: 699–705.
DOI: 10.1007/s13365-023-01182-8 |
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Fořtová A.,
Hönig V.,
Salát J., Palus M., Pýchová M., Krbková L., Barkhash A.V., Kříha M.F., Chrdle A., Lipoldová M.,
Růžek D. (2023) Serum matrix metalloproteinase-9 (MMP-9) as a biomarker in paediatric and adult tick-borne encephalitis patients Virus Research
324: 199020.
DOI: 10.1016/j.virusres.2022.199020 |
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Kevély Á.,
Prančlová V., Sláviková M.,
Haviernik J.,
Hönig V., Nováková E., Palus M.,
Růžek D., Klempa B., Koči J. (2023) Fitness of mCherry reporter tick-borne encephalitis virus in tick experimental models Viruses-Basel
14: 2673.
DOI: 10.3390/v14122673 |
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Pilipenco A., Forinová M., Mašková H.,
Hönig V., Palus M., Scott L.N., Víšová I., Vrabcová M., Houska M., Anthi J., Spasovová M., Mustacová J.,
Štěrba J., Dostálek J., Tung C.P., Yang A.S., Jack R., Dejneka A., Hajdu J., Vaisocherová-Lísalová H. (2023) Negligible risk of surface transmission of SARS-CoV-2 in public transportation Journal of Travel Medicine
30: taad065.
DOI: 10.1093/jtm/taad065 |
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Ribeiro J.,
Hartmann D.,
Bartošová-Sojková P., Debat H.,
Moos M., Fara J.,
Šimek P., Palus M.,
Kučera M.,
Hajdušek O.,
Sojka D.,
Kopáček P.,
Perner J. (2023) Blood-feeding adaptations and virome assessment of the poultry red mite Dermanyssus gallinae guided by RNA-seq Communications Biology
6: 517.
DOI: 10.1038/s42003-023-04907-x |
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Salát J., Huňady M.,
Svoboda P., Strelcova L.,
Straková P., Fořtová A., Palus M.,
Růžek D. (2023) Efficacy and immunogenicity of a veterinary vaccine candidate against tick-borne encephalitis in dogs Vaccine
41: 6150-6155.
DOI: 10.1016/j.vaccine.2023.09.019 |
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Svoboda P., Haviernik J., Bednar P., Matkovic M., Cervantes Rincón T., Keeffe J., Palus M.,
Salát J., Agudelo M., Nussenzweig M.C., Cavalli A., Robbiani D.F.,
Růžek D. (2023) A combination of two resistance mechanisms is critical for tick-borne encephalitis virus escape from a broadly neutralizing human antibody Cell Reports
42: 113149.
DOI: 10.1016/j.celrep.2023.113149 |
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Fořtová A.,
Hönig V., Palus M.,
Salát J., Pýchová M., Krbková L.,
Vyhlídalová T., Kříha M.F., Chrdle A.,
Růžek D. (2022) Serum and cerebrospinal fluid phosphorylated neurofilament heavy subunit as a marker of neuroaxonal damage in tick-borne encephalitis Journal of General Virology
103: 1743.
DOI: 10.1099/jgv.0.001743 |
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Kovacech B., Fialova L., Filipcik P., Skrabana R., Zilkova M., Paulenka-Ivanovova N., Kovac A., Palova D., Paulikova Rolkova G., Tomkova K., Turic Csokova N., Markova K., Skrabanova M., Sinska K., Basheer N., Majerova P., Hanes J., Parrak V., Prcina M., Cehlar O., Cente M., Piestansky J., Fresser M., Novák M., Sláviková M., Borsova K., Cabanova V., Brejová B., Vinař T., Nosek J., Klempa B.,
Eyer L.,
Hönig V., Palus M.,
Růžek D.,
Vyhlídalová T.,
Straková P., Mrazkova B., Zudova D., Koubkova G,, Novosadova V., Procházka J., Sedlacek R., Zilka N., Kontsekova E. (2022) Monoclonal antibodies targeting two immunodominant epitopes on the Spike protein neutralize emerging SARS-CoV-2 variants of concern Ebiomedicine
76: 103818.
DOI: 10.1016/j.ebiom.2022.103818 |
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Migné C.V.,
Hönig V., Bonnet S.I., Palus M., Rakotobe S., Galon C., Heckmann A.,
Výletová E., Devillers E., Attoui H.,
Růžek D., Moutailler S. (2022) Evaluation of two artificial infection methods of live ticks as tools for studying interactions between tick-borne viruses and their tick vectors Scientific Reports
12: 491.
DOI: 10.1038/s41598-021-04498-9 |
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Agudelo M., Palus M., Keeffe J., Bianchini F., Svoboda P.,
Salát J., Peace A., Gazumyan A., Cipolla M., Kapoor T., Guidetti F., Yao K.H.,
Elsterová J., Teislerová D., Chrdle A.,
Hönig V., Oliveira T., West A.P., Lee Y.E., Rice C.M., MacDonald M.R., Bjorkman P.J.,
Růžek D., Robbiani D.F., Nussenzweig M.C. (2021) Broad and potent neutralizing human antibodies to tick-borne flaviviruses protect mice from disease. Journal of Experimental Medicine
218: e20210236.
DOI: 10.1084/jem.20210236 |
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Beliavskaia A.,
Hönig V.,
Erhart J.,
Vyhlídalová T., Palus M., Černý J., Kozlova I.,
Růžek D., Palomar A.M., Bell-Sakyi L. (2021) Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks. Frontiers in Veterinary Science
8: 659786.
DOI: 10.3389/fvets.2021.659786 |
